We discuss simultaneous and independent 2R regeneration of many WDM channels, enabled by a group-delay-managed nonlinear medium, in which high intra-channel nonlinearity can be accumulated without suffering from the nonlinear inter-channel crosstalk. We demonstrate, for the first time to our knowledge, simultaneous all-optical regeneration of up. Citation (APA): Wang, J. Optics Express, 22(10), 11456-11464. Vasilyev, "Multi-Channel All-Optical Signal Regeneration," in Optical Fiber Communication Conference (OFC) 2019, OSA Technical Digest (Optica Publishing Group, 2019), paper W4F. When high power launched in optical fiber, several nonlinear transmission impairment such as ampl tude noise, phase noise, power spectral losses, that degrades the performance of optical. We have proposed a novel multi-channel regeneration scheme for wavelength division multiplexed systems, which is based on four wave mixing in a highly nonlinear fiber. A 40-channel wavelength division multiplexed signal having data rate of 10 Gbps per channel is divided into five groups.